Working together with Peter Cherepanov at the Crick, we are investigating the molecular basis of retroviral intergration into host-cell chromosomes. We have determined the first subnanometre resolution structure of an enzyme bound to a nucleosome and we now want to establish how retroviral integration affects nucleosome repositioning.

Relevant papers

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A*, Cherepanov P*. A SUPRAMOLECULAR ASSEMBLY MEDIATES LENTIVIRAL DNA INTEGRATION. Science. 2017 Jan 6;355(6320):93-95. (*Corresponding authors).

Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A*, Cherepanov, P* (2015) STRUCTURAL BASIS FOR RETROVIRAL INTEGRATION INTO NUCLEOSOMES. Nature 523, 366-369. (*Corresponding authors).