PB300080.JPG
 

RESEARCH PAPERS

2018

GOSWAMI P, ABID ALI F, DOUGLAS M, LOCKE J, PURKISS A, JANSKA A, EICKHOFF P, EARLY A, NANS A, CHEUNG A, DIFFLEY JF, COSTA A. CRYO-EM STRUCTURE OF DNA-CMG-POL EPSILON ELUCIDATES THE ROLES OF ESSENTIAL, NON-CATALYTIC POLYMERASE MODULES IN THE EUKARYOTIC REPLISOME. NATURE COMMUN. IN PRESS

DOUGLAS ME, ABID ALI F, COSTA A, DIFFLEY JF. THE MECHANISM OF EUKARYOTIC CMG HELICASE ACTIVATION. NATURE, 2018 MAR 8;555(7695):265-268 (RATED ‘EXCEPTIONAL’ ON F1000.COM).

2017

ABID ALI F, DOUGLAS ME, LOCKE J, PYE VE, NANS A, DIFFLEY JF, COSTA A CRYO-EM STRUCTURE OF A LICENSED DNA REPLICATION ORIGIN. NAT. COMMUN. 2017 8 (1), 2241.

FRIGOLA J, HE J, KINKELIN K, PYE VE, RENAULT L, DOUGLAS M, REMUS D, CHEREPANOV P*, COSTA A*, DIFFLEY JF* CDT1 STABILISES AN OPEN MCM RING FOR HELICASE LOADING. NAT COMMUN 2017. IN PRESS. (*CORRESPONDING AUTHORS).

ZHOU JC, JANSKA A, GOSWAMI P, RENAULT L, ABID ALI F, KOTECHA A, DIFFLEY JF, COSTA A. CMG-POL EPSILON DYNAMICS SUGGESTS A MECHANISM FOR THE ESTABLISHMENT OF LEADING-STRAND SYNTHESIS IN THE EUKARYOTIC REPLISOME. PNAS. 2017 APR 3.

BALLANDRAS-COLAS A, MASKELL DP, SERRAO E, LOCKE J, SWUEC P, JÓNSSON SR, KOTECHA A, COOK NJ, PYE VE, TAYLOR IA, ANDRÉSDÓTTIR V, ENGELMAN AN, COSTA A*, CHEREPANOV P*. A SUPRAMOLECULAR ASSEMBLY MEDIATES LENTIVIRAL DNA INTEGRATION. SCIENCE. 2017 JAN 6;355(6320):93-95. (*CORRESPONDING AUTHORS).

2016

SWUEC P, RENAULT L, BORG A, SHAH F, MURPHY VJ, VAN TWEST S, SNIJDERS AP, DEANS AJ, COSTA A. THE FA CORE COMPLEX CONTAINS A HOMO-DIMERIC CATALYTIC MODULE FOR THE SYMMETRIC MONO-UBIQUITINATION OF FANCI-FANCD2. CELL REP. 2017 JAN 17;18(3):611-623.

SAMORA CP, SAKSOUK J, GOSWAMI P, WADE BO, SINGLETON MR, BATES PA, LENGRONNE A, COSTA A, UHLMANN F. CTF4 LINKS DNA REPLICATION WITH SISTER CHROMATID COHESION ESTABLISHMENT BY RECRUITING THE CHL1 HELICASE TO THE REPLISOME. MOL CELL. 2016 AUG 4;63(3):371-84. (PREVIEW IN MOL CELL AUG 4;63(3): 347–348).

ABID ALI F, RENAULT L, GANNON J, GAHLON HL, KOTECHA A, ZHOU JC, RUEDA D, COSTA A., CRYO-EM STRUCTURES OF THE EUKARYOTIC REPLICATIVE HELICASE BOUND TO A TRANSLOCATION SUBSTRATE. NAT. COMMUN., 2016 FEB 18;7:10708.

2015

CHAO WCH, MURAYAMA Y, MUÑOZ, S; COSTA A, UHLMANN F, SINGLETON MR (2015) STRUCTURAL STUDIES REVEAL THE FUNCTIONAL MODULARITY OF THE SCC2-SCC4 COHESIN LOADER. CELL REPORTS 12, 719-725.

MASKELL DP, RENAULT L, SERRAO E, LESBATS P, MATADEEN R, HARE S, LINDEMANN D, ENGELMAN AN, COSTA A*, CHEREPANOV, P* (2015) STRUCTURAL BASIS FOR RETROVIRAL INTEGRATION INTO NUCLEOSOMES. NATURE 523, 366-369. (*CORRESPONDING AUTHORS).

PIKE AC, GOMATHINAYAGAM S, SWUEC P, BERTI M, ZHANG Y, SCHNECKE C, MARINO F, VON DELFT F, RENAULT L, COSTA A, GILEADI O, VINDIGNI A. HUMAN RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCH MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURES. PROC NATL ACAD SCI U S A. 2015 APR 7;112(14):4286-91.

PETOJEVIC T, PESAVENTO JJ, COSTA A, LIANG J, WANG Z., BERGER JM, BOTCHAN MR, CDC45 GUARDS THE GATE IN THE CMG HELICASE STABILIZING LEADING STRAND ENGAGEMENT. PNAS. 2015 JAN 5 (EPUB). (ONE STAR ON F1000.COM).

2014

COSTA A*, RENAULT L, SWUEC P, PETOJEVIC T, PESAVENTO JJ, ILVES I, MACLELLAN-GIBSON K, FLECK RA, BOTCHAN MR*, BERGER JM*. DNA BINDING POLARITY, DIMERIZATION, AND ATPASE RING REMODELING IN THE CMG HELICASE OF THE EUKARYOTIC REPLISOME. ELIFE. 2014 AUG 12;3:E03273. (*CORRESPONDING AUTHORS, THREE STARS ON F1000.COM).

SIMON AC, ZHOU JC, PERERA RL, VAN DEURSEN F, EVRIN C, IVANOVA ME, KILKENNY ML, RENAULT L, KJAER S, MATAK-VINKOVIĆ D, LABIB K, COSTA A*, PELLEGRINI L*. A CTF4 TRIMER COUPLES THE CMG HELICASE TO DNA PO­­­LYMERASE A IN THE EUKARYOTIC REPLISOME. NATURE. 2014 JUN 12;510(7504):293-7. (*CORRESPONDING AUTHORS, RATED ‘EXCEPTIONAL’ ON F1000.COM).

2013

COULTHARD R, DEANS AJ, SWUEC P, BOWLES M, COSTA A, WEST SC, MCDONALD NQ. ARCHITECTURE AND DNA RECOGNITION ELEMENTS OF THE FANCONI ANEMIA FANCM-FAAP24 COMPLEX. STRUCTURE 2013 SEP 3;21(9):1648-58.

2012

LYUBIMOV A., COSTA A., BOTCHAN MR, BERGER JM. ATP-DEPENDENT CONFORMATIONAL DYNAMICS UNDERLIE THE FUNCTIONAL ASYMMETRY OF THE MCM2-7 COMPLEX FROM A MINIMALIST EUKARYOTE. PNAS 2012 JUL 24;109(30):11999-2004.

 

OTHER PUBLICATIONS

2018

GOSWAMI P, LOCKE J, COSTA A. PREPARING FROZEN-HYDRATED PROTEIN-NUCLEIC ACID ASSEMBLIES FOR HIGH-RESOLUTION CRYO-EM IMAGING. BOOK CHAPTER IN “NANOSCALE IMAGING: METHODS AND PROTOCOLS”. THE METHODS IN MOLECULAR BIOLOGY SERIES (SPRINGER). GUEST EDITOR YURI LYUBCHENKO. IN PRESS.

2017

EICKHOFF P, COSTA A. ESCORTING CLIENT PROTEINS TO THE HSP90 MOLECULAR CHAPERONE. STRUCTURE. 2017 JUL 5;25(7):964-965.

MILLER TC, COSTA A. THE ARCHITECTURE AND FUNCTION OF THE CHROMATIN REPLICATION MACHINERY. CURR OPIN STRUCT BIOL.  2017 APR 15;47:9-16.

WILSON MD*, COSTA A*. CRYO-ELECTRON MICROSCOPY OF CHROMATIN BIOLOGY. (*CORRESPONDING AUTHORS). ACTA CRYST D. 2017 APRIL 20; EPUB.

2016

SWUEC P, COSTA A. DNA REPLICATION AND INTER-STRAND CROSSLINK REPAIR: SYMMETRIC ACTIVATION OF DIMERIC NANOMACHINES? BIOPHYS CHEM. 2016 NOV 10.

PELLEGRINI L*, COSTA A*. NEW INSIGHTS INTO THE MECHANISM OF DNA DUPLICATION BY THE EUKARYOTIC REPLISOME. TRENDS IN BIOCHEM SCI 2016 OCT;41(10):859-71 (*CORRESPONDING AUTHORS).

ABID ALI F, COSTA A. THE MCM HELICASE MOTOR OF THE EUKARYOTIC REPLISOME. J MOL BIOL. 2016 MAY 8;428(9 PT B):1822-32.

2014

SWUEC P, COSTA A. MOLECULAR MECHANISM OF DOUBLE HOLLIDAY JUNCTION DISSOLUTION. CELL BIOSCI. 2014 JUL 9;4:36.

ZHOU JC, COSTA A, PREPARING TO UNWIND. ELIFE. 2014 APR 1;3:E02618.

2013

AZE, A., ZHOU, J.C., COSTA A.*, COSTANZO, V*. DNA REPLICATION AND HOMOLOGOUS RECOMBINATION FACTORS: ACTING TOGETHER TO MAINTAIN GENOME STABILITY. CHROMOSOMA. 2013 OCT;122(5):401-13. (*CORRESPONDING AUTHORS).

COSTA A.*, HOOD I.V.*, BERGER J.M. MECHANISMS FOR INITIATING CELLULAR DNA REPLICATION. ANNU. REV. BIOCHEM. 2013;82:25-54. (*CO-FIRST AND CO-CORRESPONDING AUTHOR).

 

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