RESEARCH PAPERS
2020
HIGASHI TL, EICKHOFF P., SOUSA JS., ..., RAPPSILBER J, COSTA A.*, UHLMANN F* A STRUCTURE-BASED MECHANISM FOR DNA ENTRY INTO THE COHESIN RING MOLECULAR CELL 79, 1–17 SEPTEMBER 17, 2020 (*CO-CORRESPONDING AUTHORS)
CONSOLATI T^, LOCKE J^, ROOSTALU J, ZHUO AC, GANNON J, ASTHANA J, LIM WM, MARTINO F, CVETKOVIC M, RAPPSILBER J, COSTA A*, SURREY T* MICROTUBULE NUCLEATION PROPERTIES OF SINGLE HUMAN GTURCS EXPLAINED BY THEIR CRYO-EM STRUCTURE. DEVELOPMENTAL CELL; 19 MAY 2020. (^CO-FIRST; *SHARED CORRESPONDING AUTHORS).
JACIUK M, SWUEC P, GAUR V, KASPRZAK JM, RENAULT L, DOBRYCHŁOP M, NIRWAL S, BUJNICKI JM*, COSTA A*, NOWOTNY M*. A COMBINED STRUCTURAL AND BIOCHEMICAL APPROACH REVEALS TRANSLOCATION AND STALLING OF UVRB ON THE DNA LESION AS A MECHANISM OF DAMAGE VERIFICATION IN BACTERIAL NUCLEOTIDE EXCISION REPAIR.
DNA REPAIR (AMST). 2020 JAN;85:102746. (*SHARED CORRESPONDING AUTHOR).
2019
MILLER TCR, LOCKE J, GREIWE JF, DIFFLEY JFX, COSTA A. MECHANISM OF HEAD-TO-HEAD MCM DOUBLE-HEXAMER FORMATION REVEALED BY CRYO-EM. NATURE. 2019 NOV;575(7784):704-710.
WILSON MD, RENAULT L, MASKELL DP, GHONEIM M, PYE VE, NANS A, RUEDA DS*, CHEREPANOV P*, COSTA A*. RETROVIRAL INTEGRATION INTO NUCLEOSOMES THROUGH DNA LOOPING AND SLIDING ALONG THE HISTONE OCTAMER. NAT COMMUN. 2019 SEP 13;10(1):4189. (*SHARED CORRESPONDING AUTHORS).
EICKHOFF P, KOSE HB, MARTINO F, PETOJEVIC T, ABID ALI F, LOCKE J, TAMBERG N, NANS A, BERGER JM, BOTCHAN MR, YARDIMCI H*, COSTA A*. MOLECULAR BASIS FOR ATP-HYDROLYSIS-DRIVEN DNA TRANSLOCATION BY THE CMG HELICASE OF THE EUKARYOTIC REPLISOME. CELL REP. 2019 SEP 3;28(10):2673-2688.E8. (*SHARED CORRESPONDING AUTHORS).
2018
GOSWAMI P, ABID ALI F, DOUGLAS M, LOCKE J, PURKISS A, JANSKA A, EICKHOFF P, EARLY A, NANS A, CHEUNG A, DIFFLEY JF, COSTA A. CRYO-EM STRUCTURE OF DNA-CMG-POL EPSILON ELUCIDATES THE ROLES OF ESSENTIAL, NON-CATALYTIC POLYMERASE MODULES IN THE EUKARYOTIC REPLISOME. NATURE COMMUN.
DOUGLAS ME, ABID ALI F, COSTA A, DIFFLEY JF. THE MECHANISM OF EUKARYOTIC CMG HELICASE ACTIVATION. NATURE, 2018 MAR 8;555(7695):265-268 (RATED ‘EXCEPTIONAL’ ON F1000.COM).
2017
ABID ALI F, DOUGLAS ME, LOCKE J, PYE VE, NANS A, DIFFLEY JF, COSTA A CRYO-EM STRUCTURE OF A LICENSED DNA REPLICATION ORIGIN. NAT. COMMUN. 2017 8 (1), 2241.
FRIGOLA J, HE J, KINKELIN K, PYE VE, RENAULT L, DOUGLAS M, REMUS D, CHEREPANOV P*, COSTA A*, DIFFLEY JF* CDT1 STABILISES AN OPEN MCM RING FOR HELICASE LOADING. NAT COMMUN 2017. IN PRESS. (*CORRESPONDING AUTHORS).
ZHOU JC, JANSKA A, GOSWAMI P, RENAULT L, ABID ALI F, KOTECHA A, DIFFLEY JF, COSTA A. CMG-POL EPSILON DYNAMICS SUGGESTS A MECHANISM FOR THE ESTABLISHMENT OF LEADING-STRAND SYNTHESIS IN THE EUKARYOTIC REPLISOME. PNAS. 2017 APR 3.
BALLANDRAS-COLAS A, MASKELL DP, SERRAO E, LOCKE J, SWUEC P, JÓNSSON SR, KOTECHA A, COOK NJ, PYE VE, TAYLOR IA, ANDRÉSDÓTTIR V, ENGELMAN AN, COSTA A*, CHEREPANOV P*. A SUPRAMOLECULAR ASSEMBLY MEDIATES LENTIVIRAL DNA INTEGRATION. SCIENCE. 2017 JAN 6;355(6320):93-95. (*CORRESPONDING AUTHORS).
2016
SWUEC P, RENAULT L, BORG A, SHAH F, MURPHY VJ, VAN TWEST S, SNIJDERS AP, DEANS AJ, COSTA A. THE FA CORE COMPLEX CONTAINS A HOMO-DIMERIC CATALYTIC MODULE FOR THE SYMMETRIC MONO-UBIQUITINATION OF FANCI-FANCD2. CELL REP. 2017 JAN 17;18(3):611-623.
SAMORA CP, SAKSOUK J, GOSWAMI P, WADE BO, SINGLETON MR, BATES PA, LENGRONNE A, COSTA A, UHLMANN F. CTF4 LINKS DNA REPLICATION WITH SISTER CHROMATID COHESION ESTABLISHMENT BY RECRUITING THE CHL1 HELICASE TO THE REPLISOME. MOL CELL. 2016 AUG 4;63(3):371-84. (PREVIEW IN MOL CELL AUG 4;63(3): 347–348).
ABID ALI F, RENAULT L, GANNON J, GAHLON HL, KOTECHA A, ZHOU JC, RUEDA D, COSTA A., CRYO-EM STRUCTURES OF THE EUKARYOTIC REPLICATIVE HELICASE BOUND TO A TRANSLOCATION SUBSTRATE. NAT. COMMUN., 2016 FEB 18;7:10708.
2015
CHAO WCH, MURAYAMA Y, MUÑOZ, S; COSTA A, UHLMANN F, SINGLETON MR (2015) STRUCTURAL STUDIES REVEAL THE FUNCTIONAL MODULARITY OF THE SCC2-SCC4 COHESIN LOADER. CELL REPORTS 12, 719-725.
MASKELL DP, RENAULT L, SERRAO E, LESBATS P, MATADEEN R, HARE S, LINDEMANN D, ENGELMAN AN, COSTA A*, CHEREPANOV, P* (2015) STRUCTURAL BASIS FOR RETROVIRAL INTEGRATION INTO NUCLEOSOMES. NATURE 523, 366-369. (*CORRESPONDING AUTHORS).
PIKE AC, GOMATHINAYAGAM S, SWUEC P, BERTI M, ZHANG Y, SCHNECKE C, MARINO F, VON DELFT F, RENAULT L, COSTA A, GILEADI O, VINDIGNI A. HUMAN RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCH MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURES. PROC NATL ACAD SCI U S A. 2015 APR 7;112(14):4286-91.
PETOJEVIC T, PESAVENTO JJ, COSTA A, LIANG J, WANG Z., BERGER JM, BOTCHAN MR, CDC45 GUARDS THE GATE IN THE CMG HELICASE STABILIZING LEADING STRAND ENGAGEMENT. PNAS. 2015 JAN 5 (EPUB). (ONE STAR ON F1000.COM).
2014
COSTA A*, RENAULT L, SWUEC P, PETOJEVIC T, PESAVENTO JJ, ILVES I, MACLELLAN-GIBSON K, FLECK RA, BOTCHAN MR*, BERGER JM*. DNA BINDING POLARITY, DIMERIZATION, AND ATPASE RING REMODELING IN THE CMG HELICASE OF THE EUKARYOTIC REPLISOME. ELIFE. 2014 AUG 12;3:E03273. (*CORRESPONDING AUTHORS, THREE STARS ON F1000.COM).
SIMON AC, ZHOU JC, PERERA RL, VAN DEURSEN F, EVRIN C, IVANOVA ME, KILKENNY ML, RENAULT L, KJAER S, MATAK-VINKOVIĆ D, LABIB K, COSTA A*, PELLEGRINI L*. A CTF4 TRIMER COUPLES THE CMG HELICASE TO DNA POLYMERASE A IN THE EUKARYOTIC REPLISOME. NATURE. 2014 JUN 12;510(7504):293-7. (*CORRESPONDING AUTHORS, RATED ‘EXCEPTIONAL’ ON F1000.COM).
2013
COULTHARD R, DEANS AJ, SWUEC P, BOWLES M, COSTA A, WEST SC, MCDONALD NQ. ARCHITECTURE AND DNA RECOGNITION ELEMENTS OF THE FANCONI ANEMIA FANCM-FAAP24 COMPLEX. STRUCTURE 2013 SEP 3;21(9):1648-58.
2012
LYUBIMOV A., COSTA A., BOTCHAN MR, BERGER JM. ATP-DEPENDENT CONFORMATIONAL DYNAMICS UNDERLIE THE FUNCTIONAL ASYMMETRY OF THE MCM2-7 COMPLEX FROM A MINIMALIST EUKARYOTE. PNAS 2012 JUL 24;109(30):11999-2004.