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COSTA LAB MEMBERS

 
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ALESSANDRO COSTA

Senior Group Leader

Laurea in Biotechnology @ University of Padova

PhD @ Imperial College with Silvia Onesti & Ardan Patwardhan

Postdoc @ Oxford with Steve Bell and Berkeley with James Berger.

I seek to use cryo-electron microscopy for high-resolution imaging of reconstituted genome replication reactions as they occur in a test tube at cellular rates.

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AGATA BUTRYN

Senior Laboratory Research Scientist

Magister in Biotechnology @ Jagiellonian University

Dr. rer. nat. @ Ludwig Maximilian University of Munich with Karl-Peter Hopfner

Postdoc and Beamline Scientist @ Diamond Light Source (XFEL-Hub) with Allen Orville

I have a background in protein-DNA biochemistry and (time-resolved) crystallography.

I work on novel sample preparation methods for single-particle cryo-electron microscopy.

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JULIA GREIWE

PhD student

Msc in Biochemistry @ Heidelberg University (working with Christoph Mueller at EMBL Heidelberg and Karim Labib in Dundee).

I study the interaction between the MCM helicase and firing factors that lead to origin activation. To this end I combined in vitro reconstituted DNA replication reactions with cryo-EM imaging.

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THOMAS PUEHRINGER

PhD student

BSc in Biology @ University of Vienna

MSc in Molecular Biology @ University of Vienna (Thesis with Clemens Plaschka @ IMP Vienna).

I study the formation of the replicative CMG helicase during origin activation by using biochemistry and cryo-EM.

I have a background in mRNA export and electron microscopy.

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MILOS CVETKOVIC

Postdoctoral training fellow

Diploma in Molecular Biology @ University of Belgrade, thesis with Olivier Bensaude at ENS Paris.

PhD @ University of Tuebingen/MPI with Remco Sprangers, Max Planck Institute

I have a background in studying large nucleic-acid-interacting protein complexes and NMR. I work on the role of helicase and polymerases in histone redeposition at the replication fork.

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JACOB LEWIS

Postdoctoral training fellow

Bachelor  Advanced Medical Biotechnology (Honours, Class I) @ University of Wollongong

PhD @ University of Wollongong with Nicholas Dixon 

Postdoc @ University of Wollongong with Antoine van Oijen

I study the mechanisms of replication for establishment. I have a background in DNA replication biochemistry and single-molecule biophysics.

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SARAH HENRIKUS

Postdoctoral training fellow

Master in Chemistry @ Universitaet des Saarlandes

PhD @ University of Wollongong with Antoine van Oijen and Andrew Robinson

I study the mechanisms of sister chromatid cohesion establishment. I have an expertise in single molecule fluorescence microscopy.

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OLIVER WILLHOFT

Postdoctoral training fellow

BSc in Biological Sciences @ University of Warwick

PhD @ ISMB (UCL/Birkbeck) with Cara Vaughan

Postdoc @ Imperial College London with Dale Wigley

I study chromatin replication using biochemistry and cryo-EM.

I have a background in the structural mechanism of chromatin remodellers.

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FORMER LAB MEMBERS