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COSTA LAB MEMBERS

 

ALESSANDRO COSTA

Senior Group Leader

Senior Group Leader

Laurea in Biotechnology @ University of Padova

PhD @ Imperial College with Silvia Onesti & Ardan Patwardhan

Postdoc @ Oxford with Steve Bell and Berkeley with James Berger.

I seek to use cryo-electron microscopy for high-resolution imaging of reconstituted genome replication reactions as they occur in a test tube at cellular rates.

JULIA LOCKE

Senior Laboratory Research Scientist

Senior Laboratory Research Scientist

Bachelor and Master in Molecular Biology @ Salzburg University

PhD @ Salzburg University

Postdoc @ Birkbeck College with Carolyn Moores.

I am a cryo-EM scientist. My role is to provide training and technical support in our group. Besides running the lab, I am involved in several collaborative research projects.

THOMAS MILLER

Postdoctoral training fellow

Postdoctoral Training Fellow

Bsc in  Biochemistry @ University of Sheffield

PhD @ LMB, University of Cambridge with Marianne Bienz

Postdoc @ EMBL Heidelberg with Christoph Mueller and Teresa Carlomagno

I study the mechanism of MCM helicase loading using in vitro reconstitution and cryo-EM. I have a background in chromatin biology, NMR and crystallography

PATRIK EICKHOFF

PhD Student

PhD student

Bsc in  Biochemistry @ UCL

Mres in Structural Molecular Biology @ Imperial College London

I study the mechanism of ATP-hydrolysis driven translocation by the active CMG helicase. I have an expertise in the reconstitution of protein-nucleic acid complexes and cryo-electron microscopy.

JULIA GREIWE

PhD student

PhD student

Msc in Biochemistry @ Heidelberg University (working with Christoph Mueller at EMBL Heidelberg and Karim Labib in Dundee).

I study the interaction between the MCM helicase and firing factors that lead to origin activation. To this end I combined in vitro reconstituted DNA replication reactions with cryo-EM imaging.

MILOS CVETKOVIC

Postdoctoral training fellow

Postdoctoral Training Fellow

Diploma in Molecular Biology @ University of Belgrade, thesis with Olivier Bensaude at ENS Paris.

PhD @ University of Tuebingen/MPI with Remco Sprangers, Max Planck Institute

I have a background in studying large nucleic-acid-interacting protein complexes and NMR. I work on the role of helicase and polymerases in histone redeposition at the replication fork.

FABRIZIO MARTINO

Senior Laboratory Research Scientist

Senior Laboratory Research Scientist

Laurea in Biology @ University of Pavia

PhD @ FMI Basel with Susan Gasser

Postdoc @ LMB Cambridge with Daniela Rhodes and CIB Madrid with Oscar Llorca

I am an expert in chromatin biology, crystallography and cryo-EM. I train lab members in model building and work on collaborative projects.

ESTHER ORTEGA

Postdoctoral training fellow

Bachelor & Master in Biochemistry @ University of Zaragoza

PhD @ University of Salamanca with Jose Maria de Pereda

Postdoc @ EMBL Grenoble with Daniel Panne

I have a background in chromatin biochemistry and crystallography. I work on parental histone recycling.

FORMER LAB MEMBERS

 

phone +44 (0)20 3796 1812